May Newsletter…

May brings flowers, warmer weather, and of course Mother’s Day.  I wanted to dedicate this month to all the lovely ladies out there, with or without kids. Obviously, I’m not excluding men from ordering any of these treatments, they just happen to be popular amongst our XY chromosome clan.
Let me start by saying if you would like to spoil your lady or mother with a wellness package please reach out to me. We can get her set up with a full lab panel and detailed plan to help her reach any of her health and wellness goals. 


This month’s special will include some vanity treatments that help slow down signs of aging, from the inside and outside. I’ll also include some bonus sexual health products because…lets face it better orgasms are the perfect mental vacation/stress relief from adulting, and exactly what the doctor orders for mom’s and our working ladies.

Lets dig right into it….

1.  Rx Strength Topical Creams for your Face

Anti-Wrinkle Rejuvenation Serum 

GHK-Cu copper peptide / Argireline / Leuphasyl

In clinical studies, the formation of facial wrinkles has been closely linked to the loss of elastic properties of the skin. Cumulative irradiation with ultraviolet (UV) B at suberythemal doses significantly reduces the elastic properties of the skin, resulting in the formation of wrinkles.

Peptides of synthesis are a very new strategy in cosmetic science and technology for at least two reasons: (1) they are small molecules, easily penetrable in the skin and (2) they are able to induce a very specific action because all skin cells (keratinocytes, fibroblasts, nervous cells) have membrane receptors for peptides. This group of cosmeceuticals includes the Botox-like peptides, represented by acetyl hexapeptide 3 (Argireline) and pentapeptid-3 (Leuphasyl).

This substance inhibits the neuromuscular synapses in the mimic muscles, acting as enkephalins. It links the enkephalin receptor to nerve cells, thereby modulating the release of acetylcholine in synaptic space.  This cellular activity will be translated in vivo in a relaxation of the muscle and a reduction of expression wrinkles.

Argireline, a mimetic of Botox, has been found to be safer than Botox and effective in reducing wrinkles, with efficacies up to 48% upon 4 weeks of twice-daily treatment.

Argireline, a synthetic peptide, which is patterned from the N-terminal end of the protein SNAP-25, can both reduce the degree of existing facial wrinkles and demonstrate effectively against their development.

GHK-Cu is a naturally occurring copper complex that was first identified in human plasma. Copper peptides are small, naturally occurring protein fragments that have a high affinity for copper ions, which are critical to normal body function.  It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. It then plays a significant role in signaling tissue remodeling, which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age.

 There are four types of wrinkles 

  1. Atrophic Crinkling Rhytids: fine lines on the face that are almost parallel to each other. They show up on different areas of the face and body but tend to disappear when the skin is stretched transversally (this just means they shift when your body posture changes). These wrinkles are associated with loss of elasticity (loss of collagen).
  1. Permanent Elastic Creases: Crease lines in the skin that become increasingly permanent over time, especially with sun exposure. They show up most frequently on the cheeks, the upper lip and the base of the neck. Sun exposure and also smoking are involved in the extension of those wrinkles.
  1. Dynamic Expression Lines: Wrinkles that are caused by facial muscle movement. Most of the facial muscles have involuntary movements. In this case, the wrinkles’ form is perpendicular to the long axis of the muscle. The relaxation of the muscles over which the skin is pulled can improve those wrinkles.
  1. Gravitational Folds: The name implies, these lines are due to the effects of gravity and become increasingly obvious as the skin begins to fold and sag. The location of these wrinkles is related to the thickness of the skin.

Anti-Aging Facial Cream

DMAE / ESTRIOL / GHK-CU / HYALURONIC ACID BIOPEPTIDE 3% / 0.3% / 0.2% / 1.5%

GHK-Cu is a naturally occurring copper complex that was first identified in human plasma. Copper peptides are small, naturally occurring protein fragments that have a high affinity for copper ions, which are critical to normal body function. Since its discovery in 1973, GHK-Cu established itself as a powerful protective and regenerative ingredient, which is currently widely used in skin and hair products. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. It then plays a significant role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age.

South Lake Pharmacy compounds GHK-Cu in a Biopeptide Biocosmetic base specifically designed to help tackle wrinkles once and for all! This advanced phosphate based emulsion system is packed with high concentrations of the two biopeptides palmitoyl tripeptide-3 and palmitoyl pentapeptide-3. This is an elegant cream designed for cosmetic facial use.

  • Tighten loose skin and reverse thinning of aged skin.
  • Repair protective skin barrier proteins.
  • Improve skin firmness, elasticity, and clarity.
  • Reduce fine lines, depth of wrinkles, and improve the structure of aged skin
  • Smooth rough skin.
  • Reduce photo damage, mottled hyperpigmentation, skin spots, and lesions.
  • Improve overall skin appearance.
  • Stimulate wound healing.
  • Protect skin cells from UV radiation.
  • Reduce inflammation and free radical damage.

Have a look at the Studies

The role of dimethylaminoethanol in cosmetic dermatology.

Mitigation forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends (p > 0.05 but </= 0.1) were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness. The application was found to be well tolerated, with no differences in the incidence of erythema, peeling, dryness, itching, burning, or stinging between the DMAE and placebo groups

Hyaluronic acid: A key molecule in skin aging

The key molecule involved in skin moisture is hyaluronic acid (HA) that has a unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association, and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

Treatment of skin aging with topical estrogens.

After treatment for 6 months, elasticity and firmness of the skin had markedly improved and the wrinkle depth and pore sizes had decreased by 61 to 100% in both groups. Furthermore, skin moisture had increased and the measurement of wrinkles using skin profilometry, revealed significant, or even highly significant, decreases of wrinkle depth in the estradiol and the estriol groups, respectively. On immunohistochemistry, significant increases of Type III collagen labeling were combined with increased numbers of collagen fibers at the end of the treatment period. As to hormone levels, only those of PRL had increased significantly and no systemic hormonal side effects were noted.

2.  Tanning Injections

Melanotan II

Melanotan II is a non-selective agonist of the melanocortin receptors which was originally developed as a tanning peptide. Hence the reason the peptide was marketed as the “Barbie” peptide with its binding ability to MCR1. Melanotan II is a synthetic cyclic lactam analog of naturally occurring α-MSH (melanocyte-stimulating hormone), a trimmed version of Melanotan I with a longer half-life.   Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. Melanocyte stimulating hormone (MSH) has been shown to control skin coloration/pigmentation in humans. The pigment melanin is produced in melanosomes by melanocytes in a complex process called melanogenesis. Melanin is the principal determinant factor of skin, hair, and eye color. It has a significant role in photoprotection due to its ability to absorb ultraviolet radiation (UVR). Melanocytes interact intrinsically with endocrine, immune, inflammatory, and central nervous systems. Its activity is regulated by extrinsic factors such as ultraviolet radiation and drugs.  Melanotan II has the same mechanism as Melanotan I but does cross the blood-brain barrier. There are five melanocortin receptors MC1R – MC5R. These receptors have been identified to show specific tissue 

expression patterns and binding affinities for each of the melanocortin hormones. The central melanocortin system MC3R & MC4R receptors play a fundamental role in the control of feeding and body weight.

  • Supports Melanogenesis.
  • Tanning.
  • Photoprotective.
  • Lessens appetite and improves lipid and glucose regulation.
  • Libido enhancement (more of a side effect at a high dose).
  • Metabolic Support:  Lipolytic, appetite control, anti-inflammatory, lowers oxidative stress.
  • Induces enhanced thermogenic and anorexic responses via MC4R binding, and helps improve glucose and cholesterol metabolism.
  • Immune – activates Treg cells and improves Th1/Th17 balance.
  • Autoimmune conditions.

Protocol

Tanning: Reconstitute with 5mL’s BAC water. Inject 10 units (200mcg) Sub Q daily for the first two weeks. Inject 5 units (100mcg) two-three times per week after for maintenance. Adjust accordingly to pigment changes.

Metabolic Enhancement: Reconstitute with 10mL’s of BAC water. Inject 5 units (50mcg) Sub Q daily. 

Immunity: Reconstitute with 5mL’s BAC water. Inject 10 units (200mcg) Sub Q daily for six to eight weeks until effects are pronounced.

Melanotan II IPS Monograph (Studies)

Melanotan II Study (Studies)

3. Sexual Health and Enhancement

Scream Cream
-This is a topical cream that creates higher sensitivity for the clitoris about 5 to 10 minutes after it is applied. It’s safe to enter the vagina during intercourse and provides some stimulation for your partner as well. I sent samples out for feedback and the women responded with you need a very large pea size when rubbing it on and it works well. The men reported no oral effects, just that it has a very minty taste.  

Sextacy

PT141/Cialis/Oxytocin Rapid Dissolve Tablets

Pt141 directly increases sexual desire via the nervous system. It will increase sexual frequency, boost sex drive, treatment for men and women with hypoactive sexual desire disorder, raise sexual desire, increase female sexual function index total score and female sexual distress scale-desire/arousal/orgasm total score.

Cialis, also known as tadalafil directs blood flow to the area being stimulated.  The effects can last up to 36 hours. 

Oxytocin causes genital nerves to fire spontaneously, which leads to orgasm and a heightened sexual experience overall.  One bottle can last 2 weeks to a month depending on frequency of use.

Bedroom Bliss

PT141 (Bremelanotide)
Its in treating erectile dysfunction in men and sexual arousal disorder in women.  It causes spontaneous erections and arousal.  Unlike Viagra and other related medications, it does not act upon the vascular system but directly increases sexual desire via the nervous system.

• Increase sexual frequency.

• Boost sex drive.

• Treatment for men and women with hypoactive sexual desire disorder.

• Raise sexual desire.

• Increase female sexual function index total score and female sexual distress scale-desire/arousal/orgasm total score.

  -TO BE COMBINED WITH Ginger/B6 500mg/37.5mg capsules TO COMBAT NAUSEA

Oxytocin Nasal Spray

Oxytocin causes genital nerves to fire spontaneously, which leads to orgasm and a heightened sexual experience overall.  One bottle can last 2 weeks to a month depending on frequency of use.

Pricing

Anti-wrinkle Serum $220 discounted $190

Anti-aging facial cream $220  discounted $190

  • Both $320
  • These last for a few months, only a small amount is needed

Tanning Injections $245 discounted $195

Scream Cream 5gm $86 discounted $66

Sextacy (per tablet) $10 discounted $7

Bedroom Bliss $230 discounted $189 (lasts between 1-3 months)

Oxytocin Nasal Spray $185 discounted $155

If you need any additional information or want to bundle any of these treatments together please let me know. If you know anyone who might be interested in any of our treatments please pass the word along. I will provide gifts to all our patients that refer me to new patients. I appreciate you all and hope I can help assist with all your wellness goals.
Wish you mothers a happy Mother’s Day! I’ll be playing pranks on my son all day, it’s my day and paybacks make me smile. LOL 

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