Hair Loss Foam

Minoxidil acts by shortening the telogen phase and thus causing the quiescent hair follicles to enter prematurely into the anagen phase. The shortening of the telogen phase may induce telogen effluvium after the initiation of minoxidil therapy. Also, minoxidil extends the duration of the anagen phase. Lastly, increased hair length and diameter is a clinical effect of minoxidil.  Minoxidil appears to act on the potassium channels of vascular smooth muscles and hair follicles, which may induce the following effects:

• Stimulation of the microcirculation near the hair follicles by inducing arteriolar vasodilation, which may cause hair growth
• Induction of vascular endothelial growth factor (VEGF) expression increases vascularization around the hair follicles, thus contributing to hair growth
• Activation of the prostaglandin-endoperoxide synthase one which stimulates hair growth
• Inhibition of androgen effects on the androgen-sensitive hair follicles
• Direct stimulation of the hair follicles: Minoxidil may act as an ‘epidermal growth factor’ on matrix cells delaying their aging, thus prolonging the duration of the anagen phase, via the activation of the beta-catenin pathway