As its name suggests, DSIP promotes sleep. In fact, DSIP promotes a particular type of sleep which is characterized by an increase in the delta rhythm of the EEG. Delta sleep-inducing peptide (DSIP) is a naturally occurring peptide that is normally synthesized in the hypothalamus and targets multiple sites, including some within the brainstem. DSIP has been described as a sleep-promoting substance rather than a sedative. There is a modulating effect on sleep and wake functions with more significant activity in circumstances where sleep is disturbed. When single and multiple injections of DSIP were given in a controlled, double-blind study, disturbed sleep was normalized, and better performance and increased alertness were seen during awake cycles together with improved stress tolerance and coping behavior. In addition to sleep, the peptide also has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs, including their withdrawal.
During the active, awake state, DSIP induced higher alertness and better performance.
improved stress tolerance and coping ability.
improved night sleep with the first and additionally with repeated doses